Including the effects of Post-transcriptional processing in order to improve the analysis of surveys of GeneChips
William B. Langdon, Renata da Silva Camargo, Joanna Rowsell, Jose Manuel Arteaga, Graham Upton and Andrew P. Harrison
Department of Biological Sciences & Department of Mathematical Sciences at
University of Essex
Some genes are represented by multiple probe-sets.
If they are measuring the same gene the signals should be up and down regulated together!
Is that always true?
Stalteri and Harrison, 2007, BMC Bioinformatics, 8:13.
Probes map to different exons.
Because of alternative splicing, some of the exons may be upregulated whereas others may be downregulated.
Probes map to different sides of a polyadenylation signal. Because of alternative polyadenylation, some of the probes may be upregulated whereas others may be downregulated.
Some probes can be used to study the expression of intergenic exons in
A heat-map of the correlation between probes for the same gene across 6685
13-14 December 2007.
W. B. Langdon
8 Jan 2008.