Contact Information and Personal Details
 
 

Address	Bioinformatics Group, Department of Computer Science,  University College London,  Gower Street,  London WC1E 6BT UK Tel: 44 (0) 20 76797981
E-mail	l.mcguffin@cs.ucl.ac.uk
WWW	http://www.cs.ucl.ac.uk/staff/L.McGuffin/
Date of Birth	01/10/76
Nationality	British

 

Current Position
 
 

05/2002-present

University College, London - Post Doctoral Research Fellow on the e-Protein project: The development of a distributed pipeline for structure based proteome annotation using Grid technology (http://www.e-protein.org).

Previous positions
 
 

08/01/02-04/2002	Data Manager for the Social, Genetic & Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings College, London
01/10/2001-31/12/2001	Scientific Consultant for Inpharmatica Ltd., London - Benchmarking and improving automatic protein fold recognition software for genome annotation.

Education
 
 

01/2000-04/2002	Brunel University, Uxbridge - Completion of PhD. in Bioinformatics (moved with supervisor) - Research and development of protein structure prediction software.
10/1998-01/2000	University of Warwick, Coventry - PhD. in Bioinformatics - Research and development of protein structure prediction software.
09/1995-07/1998	Queen Mary College, University of London - BSc. (Hons) in Genetics, Upper Second Class

Awards

• Biotechnology and Biological Sciences Research Council (BBSRC) special award PhD studentship (1998-2001).

Publications

Thesis:

• McGuffin, L. J.(2002) Fully automated methods for protein fold recognition using predicted secondary structure. PhD thesis, Institute of Cancer Genetics and Pharmacogenomics, Department of Biological Sciences, Brunel University.

Papers:

• Ward, J. J., Sodhi, J. S. McGuffin, L. J. , Buxton, B. F. & Jones, D. T. (2004) Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J. Mol. Biol., In press.
• McGuffin, L. J., Street, S., Bryson K., Sorensen, S. A. & Jones, D. T. (2004) The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms. Nucleic Acids Res., 32, D196-D199.
• McGuffin, L. J., Street, S., Sorensen, S. A. & Jones, D. T. (2003) The Genomic Threading Database. Bioinformatics, 20, 131-132.
• Jones, D. T. & McGuffin, L. J. (2003) Assembling Novel Protein Folds from Super-secondary Structural Fragments. Proteins: Structure, Function and Genetics, 53 (S6), 480-485.
• Ward, J. J., McGuffin, L. J., Buxton, B. F. & Jones, D. T. (2003) Secondary structure prediction using support vector machines. Bioinformatics, 19, 1650-1655.
• McGuffin, L. J. & Jones, D. T. (2003) Improvement of the GenTHREADER method for genomic fold recognition. Bioinformatics, 19, 874-881.
• McGuffin, L. J. & Jones, D. T. (2003) Benchmarking protein secondary structure prediction for protein fold recognition. Proteins, 52, 166-175.
• Marsden, R., McGuffin, L. J. & Jones, D. T. (2002) Rapid protein domain assignment from amino acid sequence using predicted secondary structure. Protein Science, 11, 2814-2824s.
• McGuffin, L. J. & Jones, D. T. (2002) Targeting novel folds for structural genomics. Proteins: Structure, Function and Genetics 48, 44-52.
• McGuffin, L. J., Bryson, K. & Jones, D. T. (2001) What are the baselines for protein fold recognition? Bioinformatics 17, 63-72.
• McGuffin, L. J., Bryson, K. & Jones, D. T. (2000) The PSIPRED protein structure prediction server. Bioinformatics 16, 404-405.

• McGuffin, L. J. & McGuffin P.(2003) Review of: Bioinformatics - From Genomes to Drugs, Thomas Lengauer (Ed.), Wiley-VCH, 2002, in Addiction Biology, 8, 255 - 257.
• McGuffin, L. J., Bryson, K. & Jones, D. T. (1999) An electronic article on the PSIPRED protein structure prediction server. BBSRC CCP11 Newsletter, 8.

• McGuffin, L. J. et al. (2002) A distributed pipeline for structure based proteome annotation using grid technology, Fifth Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction, Asilomar CA, USA
• Jones, D. T & McGuffin, L. J. (2002) Fold recognition using THREADER and GenTHREADER, Fifth Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction, Asilomar CA, USA
• Jones, D. T, Ward, J. J. & McGuffin, L. J. (2002) FRAGFOLD, PSIPRED and DISOPRED: Methods for prediction of new folds and elements of local structure, Fifth Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction, Asilomar CA, USA
• McGuffin, L. J. et al. (2002) eProtein: a distributed pipeline for structure based proteome annotation using grid technology, e-Science All hands meeting, Sheffield, UK
• McGuffin, L. J. & Jones, D. T. (2001) Targeting proteins with novel folds for structural genomics, for the 9th International Conference on Intelligent Systems for Molecular Biology, Copenhagen, Denmark

• Nucleic Acids Research, Oxford University Press journals.
• PROTEINS: Structure, Function and Genetics, Wiley-Liss.
• Bioinformatics, Oxford University Press journals.

References

1. Prof. David T. Jones, Director, Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Tel: 020 7679 7982 (+44 20 7679 7982)

E-mail: d.jones@cs.ucl.ac.uk
 

2. Prof. Rob Newbold, Director, Institute of Cancer Genetics and Pharmacogenomics, Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom

Tel: 01895 274000 (+44 1895 274000)

E-mail: rob.newbold@brunel.ac.uk
 

3. Dr Kevin Bryson, Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Tel: 020 7679 7981 (+44 20 7679 7981)

E-mail: k.bryson@cs.ucl.ac.uk