Medical Imaging on the ReaCTor: an E-Science Demonstrator

 

A.Steed[1], D. Alexander, P. Cook, C. Parker

Department of Computer Science, University College London.

 

Overview

 

Visualisation of 3D medical image volumes of the human brain is an important issue for diagnosis of pathologies and pre-surgical planning as well as basic understanding of anatomy. The development of effective visualisation tools is hard enough for standard imaging data, such as MR and PET measurements, but has become critical with the introduction of new modalities such as diffusion, perfusion, functional and permeability imaging, in which considerably more information is gathered. In diffusion imaging, for example, the measurement acquired at each voxel in the image is a complex shape describing the local connectivity of tissue, which is particularly useful in the brain, [Pierpaoli, et al, Diffuse Tensor Imaging of the Human Brain, Radiology, 1996]. At UCL-CS, we have developed interactive immersive visualisation tools for this type of data. One example view from this system can be seen in Figure 1.

 


 


Figure 1: User re-configuring the visualisation within the ReaCTor.

Technology

 

The demonstration uses the UCL ReaCTor, an Immersive Projection Technology (IPT) system similar to a CAVEô. The ReaCTor is powered by an SGI Onyx2 with four Infinite Reality2 pipes and 8 processors. The ReaCTor is a four-sided device, with three walls and a floor.

 

The 3D voxel data is presented in head-tracked stereo in real-time and the immersed user is provided with a variety of configuration and exploration tools. The user can collaborate with a colleague on another facility, either another IPT or a desktop system.

 

The example data set shown in Figure 1 is a diffusion-weighted MRI scan comprising a 128x128x42 voxel space with each voxel representing 1.7x1.7x2.5mm. The visualisation comprises three main parts: textured cut-planes showing the raw data set; arrays of polyhedra, coloured by the degree of anisotropy and directed by the principle component of the diffusion tensor; and 3D tracks extracted by tracking neuronal fibre pathways through the voxel space [Conturo, et al, Tracking Neuronal Fiber Pathways in the Living Human Brain, Proc. Natl. Acad. Sci. USA, Vol 96, pp 10422-10427].

 

Tracks are computed using either matrix or eigenvector interpolation of the data set [Kindlmann, et al, Strategies for Direct Volume Rendering of Diffusion Tensor Fields, IEEE Transactions on Visualization and Computer Graphics, 6(2)]. This is done remotely on a Beowulf cluster. We are currently using 72 nodes of a 256-node cluster within the department. The users can interactively select 3D regions from which seed points are extracted and sent to the Beowulf for path extraction. This is parallel process that can start to return results within a few hundred ms. A selection region might result in 3-4000 tracks which would take about five seconds to compute in total.

Experience and Future Work

 

This is an early stage demonstrator, but it is already providing a platform for novel medical imaging work. We will be evaluating the visualisation itself with colleagues from neuro-science. Under the Equator project (see following paragraph) we will also do studies of how users actually collaborate in the shared space, following up previous work on the asymmetries in IPT to desktop interaction [Steed, et al., Solving a 3D Cube Puzzle in a Collaborative Virtual Environment: As Good as Really Being There Together?, Technical Sketch, ACM SIGGRAPH 2001].

 

Steed is UCL principal investigator in the UK EPSRCís Interdisciplinary Research Centre, Equator. Equator is tackling the broad issues of merging physical and digital artefacts, an area known as ubiquitous computing or mixed-reality systems. Alexander is one of the UCL investigators in a similar IRC on Medical Imaging. These IRCs are heavily involved in the UK E-Science programme, and they provide quite different viewpoints on E-Science and GRID initiatives. We hope that this will be the first in a series of applications that exploit the resources and technical knowledge of both IRCs and the emerging GRID infrastructure.

 

 

 



[1] Author for correspondence, A.Steed@cs.ucl.ac.uk, Department of Computer Science, University College London, Gower St, London, WC1E 6BT